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Article

Histamine deficiency suppresses murine haptoglobin production and modifies hepatic protein tyrosine phosphorylation.

Cellular and molecular life sciences : CMLS - 1 May 2001

Hegyi K, Fülöp A K, Tóth S, Buzás E, Watanabe T, Ohtsu H, Ichikawa A, Nagy A, Falus A

Abstract excerpt

Histidine decarboxylase (HDC) synthesizes endogenous histamine from histidine in mammals. HDC-deficient mice (HDC-/-), if kept on a histamine-free diet, have no histamine in their tissues. HDC-/- mice show multiple phenotypes. In this study we show that both the constitutively expressed and turpentine-induced level of an acute-phase protein, haptoglobin, is significantly lower in the serum of HDC-/- mice compared...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11437244
DOI: 10.1007/pl00000906
PMCID: PMC11337356

Genes

HDC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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