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Article

Label-free cell phenotypic profiling of histamine H4R receptor and discovery of non-competitive H4R antagonist from natural products.

Bioorganic chemistry - 1 Jun 2024

Tang Hongming, Hou Tao, Zhou Han, Liao Han, Xu Fangfang, Xie Xiaomin, Yuan Wenjie, Guo Zhixin, Liu Yanfang, Wang Jixia, Zhou Weijia, Liang Xinmiao

Abstract excerpt

Histamine 4 receptor (H4R), the most recently identified subtype of histamine receptor, primarily induces inflammatory reactions upon activation. Several H4R antagonists have been developed for the treatment of inflammatory bowel disease (IBD) and atopic dermatitis (AD), but their use has been limited by adverse side effects, such as a short half-life and toxicity. Natural products, as an important source of...

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PMID: 38643561
DOI: 10.1016/j.bioorg.2024.107387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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