Article
Histamine receptor 2 modifies iNKT cell activity within the inflamed lung.
Allergy - 1 Dec 2017
Ferstl R, Frei R, Barcik W, Schiavi E, Wanke K, Ziegler M, Rodriguez-Perez N, Groeger D, Konieczna P, Zeiter S, Nehrbass D, Lauener R, Akdis C A, O'Mahony L
Abstract excerpt
BACKGROUND: Histamine is a key immunoregulatory mediator and can dampen proinflammatory responses via activation of histamine receptor 2 (H2 R). The aim of this study was to determine the role of H2 R in modulating lung inflammatory responses. METHODS: H2 R was blocked using famotidine or activated using dimaprit in both the ovalbumin (OVA) and house dust mite extract (HDM) murine models of respiratory...
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