Article
Negative regulatory effect of histamine in DNFB-induced contact hypersensitivity.
International immunology - 1 Dec 2004
Garaczi Edina, Széll Márta, Jánossy Tamás, Koreck Andrea, Pivarcsi Andor, Buzás Edit, Pos Zoltán, Falus András, Dobozy Attila, Kemény Lajos
Abstract excerpt
Histamine plays an important role in the regulation of various immunological functions. To evaluate the role of histamine in contact hypersensitivity, contact dermatitis was induced with dinitrofluorobenzene (DNFB) in histidine decarboxylase knockout (HDC-/-) histamine-deficient and wild-type mice. The DNFB-induced increase of the ear thickness was significantly higher in HDC-/- mice than in wild-type mice. Using...
Topics
- Animals
- Cytokines
- Dermatitis, Allergic Contact
- Dinitrofluorobenzene
- Ear
- Gene Expression
- Histamine
- Histidine Decarboxylase
- Interferon-gamma
- Interleukin-2
- Interleukin-4
- Leukocyte Common Antigens
- Leukocytes