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Article

Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer

3 Apr 2006

Abstract excerpt

BACKGROUND: Thymidylate synthase (TS) is a critical target for cancer chemotherapy and is one of the most extensively studied biomarkers for fluoropyrimidine-based chemotherapy. In addition to its critical role in enzyme catalysis, TS functions as an RNA binding protein to regulate the expression of its own mRNA translation and other cellular mRNAs, such as p53, at the translational level. In this study, a...

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PMID: 16584549
DOI: 10.1186/1471-2164-7-68

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