Article
Breast cancer family history and allele-specific DNA methylation in the legacy girls study.
Epigenetics - 1 Jan 2018
Wu Hui-Chen, Do Catherine, Andrulis Irene L, John Esther M, Daly Mary B, Buys Saundra S, Chung Wendy K, Knight Julia A, Bradbury Angela R, Keegan Theresa H M, Schwartz Lisa, Krupska Izabela, Miller Rachel L, Santella Regina M, Tycko Benjamin, Terry Mary Beth
Abstract excerpt
Family history, a well-established risk factor for breast cancer, can have both genetic and environmental contributions. Shared environment in families as well as epigenetic changes that also may be influenced by shared genetics and environment may also explain familial clustering of cancers. Epigenetic regulation, such as DNA methylation, can change the activity of a DNA segment without a change in the sequence;...
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