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Article

Analysis of Epigenetic Alterations in Homologous Recombination DNA Repair Genes in Male Breast Cancer.

International journal of molecular sciences - 14 Apr 2020

André Saudade, P Nunes Sandra, Silva Fernanda, Henrique Rui, Félix Ana, Jerónimo Carmen

Abstract excerpt

BACKGROUND: Male breast cancer (BC) is a distinct neoplasm with low but rising incidence, frequently diagnosed as advanced stage disease. Considering the relevance of altered homologous recombination repair (HRR) in male BC, we aimed to explore the biomarker potential of aberrant promoter methylation of ATM, BRCA1, PALB2, RAD51B, and XRCC3. METHODS: Formalin-fixed paraffin-embedded (FFPE) tissue samples from 128...

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Share to Biomarkers, Tumor
Share to Breast Neoplasms, Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Gene Expression Regulation, Neoplastic

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Share to Recombinational DNA Repair

Source

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Identifiers

PMID: 32295201
DOI: 10.3390/ijms21082715
PMCID: PMC7215617

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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