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Article

Transmembrane helix hydrophobicity is an energetic barrier during the retrotranslocation of integral membrane ERAD substrates.

Molecular biology of the cell - 15 Jul 2017

Guerriero Christopher J, Reutter Karl-Richard, Augustine Andrew A, Preston G Michael, Weiberth Kurt F, Mackie Timothy D, Cleveland-Rubeor Hillary C, Bethel Neville P, Callenberg Keith M, Nakatsukasa Kunio, Grabe Michael, Brodsky Jeffrey L

Abstract excerpt

Integral membrane proteins fold inefficiently and are susceptible to turnover via the endoplasmic reticulum-associated degradation (ERAD) pathway. During ERAD, misfolded proteins are recognized by molecular chaperones, polyubiquitinated, and retrotranslocated to the cytoplasm for proteasomal degradation. Although many aspects of this pathway are defined, how transmembrane helices (TMHs) are removed from the...

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Identifiers

PMID: 28539401
DOI: 10.1091/mbc.E17-03-0184
PMCID: PMC5509421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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