Article
Evidence of tumor microsatellite instability in gastric cancer with familial aggregation.
Familial cancer - 1 Jan 2009
Pedrazzani Corrado, Corso Giovanni, Velho Sérgia, Leite Marina, Pascale Valeria, Bettarini Francesca, Marrelli Daniele, Seruca Raquel, Roviello Franco
Abstract excerpt
About 90% of gastric cancer (GC) cases appear in a sporadic setting. Nonetheless, in high incidence areas high familial aggregation rates have been recently described. Microsatellite instability (MSI) is thought to be an important molecular phenotype both in sporadic GC and in tumors of the HNPCC spectrum. The aim of this study was to assess the frequency of MSI in GC with familial aggregation. Five...
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