Article
Microsatellite instability in multiple nonfamilial malignancies.
Molecular carcinogenesis - 1 Mar 2006
Niv Eva, Bomstein Yonit, Bernheim Joelle, Lishner Michael
Abstract excerpt
Development of multiple tumors of different histopathologic types may suggest a profound generalized genetic defect, such as malfunction of DNA mismatch repair (MMR) mechanism. Defects in this mechanism are best reflected in microsatellite instability (MSI). We aimed to determine the role of MSI in a group of patients with dual malignancies and compared the data with that of patients with a single malignancy....
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