Article
Tumor microsatellite instability in early onset gastric cancer.
The Journal of molecular diagnostics : JMD - 1 Oct 2005
Bacani Julinor, Zwingerman Rhonda, Di Nicola Nando, Spencer Samantha, Wegrynowski Trish, Mitchell Kyle, Hay Kazuko, Redston Mark, Holowaty Eric, Huntsman David, Pollett Aaron, Riddell Robert, Gallinger Steven
Abstract excerpt
Gastric cancer (GC) remains a leading cause of cancer mortality worldwide. Genetic factors are implicated, including DNA mismatch repair (MMR) deficiency manifested as tumor microsatellite instability (MSI). However, a standardized panel of markers and a definition of low-versus-high level MSI in GC are lacking. We examined a population-based cohort of early onset (<or=50 yrs) gastric cancer. We identified 211...
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