Article
Familial aggregation of gastric cancer with microsatellite instability.
Acta chirurgica Belgica - 1 Oct 2018
Polom Karol, Marrelli Daniele, Voglino Costantino, Roviello Giandomenico, De Franco Lorenzo, Vindigni Carla, Generali Daniele, Roviello Franco
Abstract excerpt
BACKGROUND: Microsatellite instability (MSI) is currently a new molecular subtype of gastric cancer (GC). About 90% of GC cases appear sporadically. MSI seems to be responsible for both sporadic and familial GC. The aim of this study was to analyze the frequency of MSI in GC with familial history of GC. METHODS: The MSI analysis was conducted using five quasi-monomorphic mononucleotide repeats: BAT-26, BAT-25,...
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