Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dual gating mechanism and function of P2X7 receptor channels.

Biophysical journal - 18 Jun 2013

Khadra Anmar, Tomić Melanija, Yan Zonghe, Zemkova Hana, Sherman Arthur, Stojilkovic Stanko S

Abstract excerpt

The ATP-gated P2X7 receptor channel (P2X7R) operates as a cytolytic and apoptotic receptor but also controls sustained cellular responses, including cell growth and proliferation. However, it has not been clarified how the same receptor mediates such opposing effects. To address this question, we have combined electrophysiological, imaging, and mathematical studies using wild-type and mutant rat P2X7Rs....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to HEK293 Cells
Share to Ion Channel Gating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kinetics

Share to Models, Biological

Share to Mutation

Share to Receptors, Purinergic P2X7

Source

Open in PubMed Open full text

Identifiers

PMID: 23790369
DOI: 10.1016/j.bpj.2013.05.006
PMCID: PMC3686336

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dual gating mechanism and function of P2X7 receptor channels.PMID 23790369Read ↗

Identification of residues in the first transmembrane domain of the P2X7 that regulates receptor trafficking, sensitization, and dye uptake function.Semantic proximity Read ↗

PIP(2) regulates the ionic current of P2X receptors and P2X(7) receptor-mediated cell death.Semantic proximity Read ↗

Splice variants of the P2X7 receptor reveal differential agonist dependence and functional coupling with pannexin-1.Semantic proximity Read ↗

Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives.Semantic proximity Read ↗

Functional characterization of mutants in the transmembrane domains of the rat P2X7 receptor that regulate pore conductivity and agonist sensitivity.Semantic proximity Read ↗

Allosteric modulation of ATP-gated P2X receptor channels.Semantic proximity Read ↗

ATP in the tumour microenvironment drives expression of nfP2X7, a key mediator of cancer cell survivalSemantic proximity Read ↗

Molecular dissection of purinergic P2X receptor channels.Semantic proximity Read ↗

[Structual and functional dynamics of the ATP receptor channel P2X(2)].Semantic proximity Read ↗

Agonist antagonist interactions at the rapidly desensitizing P2X3 receptor.Semantic proximity Read ↗

Expression level of P2X7 receptor is a determinant of ATP-induced death of mouse cultured neuronsSemantic proximity Read ↗

Heteromultimeric P2X(1/2) receptors show a novel sensitivity to extracellular pH.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.