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Article

Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.

Molecular cell - 3 Nov 2016

Hoa Nguyen Ngoc, Shimizu Tsubasa, Zhou Zhong Wei, Wang Zhao-Qi, Deshpande Rajashree A, Paull Tanya T, Akter Salma, Tsuda Masataka, Furuta Ryohei, Tsutsui Ken, Takeda Shunichi, Sasanuma Hiroyuki

Abstract excerpt

The Mre11/Rad50/Nbs1 complex initiates double-strand break repair by homologous recombination (HR). Loss of Mre11 or its nuclease activity in mouse cells is known to cause genome aberrations and cellular senescence, although the molecular basis for this phenotype is not clear. To identify the origin of these defects, we characterized Mre11-deficient (MRE11-/-) and nuclease-deficient Mre11 (MRE11-/H129N) chicken...

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PMID: 27814490
DOI: 10.1016/j.molcel.2016.10.011

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MRE11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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