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Article

Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.

DNA repair - 6 Aug 2009

Zhou Tong, Akopiants Konstantin, Mohapatra Susovan, Lin Peck-Sun, Valerie Kristoffer, Ramsden Dale A, Lees-Miller Susan P, Povirk Lawrence F

Abstract excerpt

Although tyrosyl-DNA phosphodiesterase (TDP1) is capable of removing blocked 3' termini from DNA double-strand break ends, it is uncertain whether this activity plays a role in double-strand break repair. To address this question, affinity-tagged TDP1 was overexpressed in human cells and purified, and its interactions with end joining proteins were assessed. Ku and DNA-PKcs inhibited TDP1-mediated processing of...

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Source

Open in PubMed Open full text

Identifiers

PMID: 19505854
DOI: 10.1016/j.dnarep.2009.05.003
PMCID: PMC2763370

Genes

TDP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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