Article
The pH shift and precursor feeding strategy in a low-toxicity FR-008/candicidin derivative CS103 fermentation bioprocess by a mutant of Streptomyces sp. FR-008.
Applied biochemistry and biotechnology - 1 Dec 2009
Mao Xiangzhao, Wang Feng, Zhang Jianguo, Chen Shi, Deng Zixin, Shen Yaling, Wei Dongzhi
Abstract excerpt
CS103, the novel derivative of polyene macrolides antibiotic FR-008/candicidin with lower toxicity has been isolated from the culture mycelia of the mutant of Streptomyces sp. FR-008, with targeted deletions of the fscP cytochrome P450 gene from its chromosome. To enhance biosynthesis of CS103, pH shift and precursor feeding strategy for fermentation process by the mutant of Streptomyces sp. FR-008 in a stirred...
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