Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparative metabolomics analysis of amphotericin B high-yield mechanism for metabolic engineering.

Microbial cell factories - 9 Mar 2021

Zhang Bo, Chen Yu, Jiang Sheng-Xian, Cai Xue, Huang Kai, Liu Zhi-Qiang, Zheng Yu-Guo

Abstract excerpt

BACKGROUND: The polyene macrocyclic compound amphotericin B (AmB) is an important antifungal antibiotic for the clinical treatment of invasive fungal infections. To rationally guide the improvement of AmB production in the main producing strain Streptomyces nodosus, comparative metabolomics analysis was performed to investigate the intracellular metabolic changes in wild-type S. nodosus ZJB20140315 with low-yield...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Amphotericin B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fermentation

Share to Industrial Microbiology

Share to Metabolic Engineering

Share to Metabolic Networks and Pathways

Share to Metabolomics

Share to Streptomyces

Source

Open in PubMed Open full text

Identifiers

PMID: 33750383
DOI: 10.1186/s12934-021-01552-z
PMCID: PMC7945361

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparative metabolomics analysis of amphotericin B high-yield mechanism for metabolic engineering.PMID 33750383Read ↗

Improvement of amphotericin B production by a newly isolated Streptomyces nodosus mutant.Semantic proximity Read ↗

Versatile filamentous fungal host highly-producing heterologous natural products developed by genome editing-mediated engineering of multiple metabolic pathwaysSemantic proximity Read ↗

Recent advances in the genome mining of Aspergillus secondary metabolites (covering 2012–2018)Semantic proximity Read ↗

Tandem mass spectral metabolic profiling of 54 actinobacterial strains and their 459 mutants.Semantic proximity Read ↗

Phenotype microarray analysis reveals the biotransformation of Fusarium oxysporum f.sp. lycopersici influenced by Bacillus subtilis PBE-8 metabolites.Semantic proximity Read ↗

Metabolic network model guided engineering ethylmalonyl-CoA pathway to improve ascomycin production in Streptomyces hygroscopicus var. ascomyceticus.Semantic proximity Read ↗

Enhanced FK506 production in Streptomyces tsukubaensis by rational feeding strategies based on comparative metabolic profiling analysisSemantic proximity Read ↗

Metabolomic analysis in Amycolatopsis keratiniphila disrupted the competing ECO0501 pathway for enhancing the accumulation of vancomycin.Semantic proximity Read ↗

Enhancement of bleomycin production in Streptomyces verticillus through global metabolic regulation of N-acetylglucosamine and assisted metabolic profiling analysisSemantic proximity Read ↗

Integrated metabolomic and genomic insights into amino acid incorporation within the hybrid polyketide-alkaloid antibiotic TLN-05220Semantic proximity Read ↗

Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entitiesSemantic proximity Read ↗

Characterization of the biosynthetic gene cluster of the polyene macrolide antibiotic reedsmycins from a marine-derived Streptomyces strainSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.