Article
Activation and enhancement of Fredericamycin A production in deepsea-derived Streptomyces somaliensis SCSIO ZH66 by using ribosome engineering and response surface methodology.
Microbial cell factories - 1 May 2015
Zhang Yonghe, Huang Huiming, Xu Shanshan, Wang Bo, Ju Jianhua, Tan Huarong, Li Wenli
Abstract excerpt
BACKGROUND: Marine microorganisms are an important source of new drug leads. However, the discovery and sustainable production of these compounds are often hampered due to the unavailable expression of cryptic biosynthetic gene clusters or limited titer. Ribosome engineering and response surface methodology (RSM) integrated strategy was developed in this study to activate cryptic gene cluster in the...
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