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Article

Mouse models of mtDNA replication diseases.

Methods (San Diego, Calif.) - 1 Aug 2010

Tyynismaa Henna, Suomalainen Anu

Abstract excerpt

Defective mitochondrial DNA (mtDNA) replication is a common cause of human disease in children and adults. mtDNA replication relies on a large set of nuclear-encoded proteins that either belong to the replication machinery itself, or participate in the nucleotide pool regulation. Identification of patient mutations in the corresponding genes has revealed that dysfunctional mtDNA replication can cause highly...

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PMID: 20385238
DOI: 10.1016/j.ymeth.2010.03.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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