Article
Mutations of rpob Gene Associated with Rifampin Resistance among Mycobacterium Tuberculosis Isolated in Tuberculosis Regional Reference Laboratory in Northeast of Iran during 2015-2016.
Ethiopian journal of health sciences - 1 May 2018
Tavanaee Sani Ashraf, Ashna Habib, Kaffash Afsaneh, Khaledi Azad, Ghazvini Kiarash
Abstract excerpt
BACKGROUND: Drug resistance is a leading concern in control of TB. Resistance against rifampin as one of the most important drugs in the treatment of Mycobacterium tuberculosis is caused by mutations in the 81-base pair region of the rpoB gene encoding the β-subunit of RNA polymerase. This study aimed to characterize the mutations in the rpoB gene associated with rifampin resistance among M. tuberculosis....
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