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Article

[Detection and characteristics of rpoB gene mutations in rifampicin-resistant clinical strains of M. tuberculosis].

Problemy tuberkuleza - 1 Jan 1999

Generozov E V, Al'tshuler M L, Govorun V M, Lopukhin Iu M, Golyshevskaia V I, Chernousova L N, Khomenko A G

Abstract excerpt

The resistance of M. tuberculosis to rifampicin, one of the key agents used in the treatment of tuberculosis is due to point mutations in the rpoB gene encoding for the B-subunit of PNA polymerase. Based on the detection of such mutations, genotypic determinations of rifampicin resistance is a serous alternative to routine microbiological assays that take much more time. Nevertheless, the efficiency of genotypic...

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PMID: 10420750

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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