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Article

Molecular analysis of rpoB gene mutation in MTB detected isolates in a tertiary care centre (AGMC) of North-East, India.

Indian journal of medical microbiology - 1 Jan 2000

Majumdar Tapan, Banik Ashmita, Allada Viswanadham, Das Banti

Abstract excerpt

BACKGROUND: Rifampicin (RIF), one of the first line drug in treatment of tuberculosis. It acts on rpoB gene which encodes RNA polymerase β subunit. In 95% of RIF resistant cases, mutations are present in rpoB gene. Most of them are within 81bp RIF-resistance determining region (RRDR).Xpert MTB/RIF assay has been tremendously revolutionalised the diagnosis of tuberculosis (TB).Also sequencially detect bacteria and...

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Identifiers

PMID: 37573058
DOI: 10.1016/j.ijmmb.2023.100399

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