Article
Does genetic variation in the Delta6-desaturase promoter modify the association between alpha-linolenic acid and the prevalence of metabolic syndrome?
The American journal of clinical nutrition - 1 Mar 2009
Truong Hong, DiBello Julia R, Ruiz-Narvaez Edward, Kraft Peter, Campos Hannia, Baylin Ana
Abstract excerpt
BACKGROUND: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with protection against components of the metabolic syndrome, but the role of alpha-linolenic acid (ALA), the metabolic precursor of EPA and DHA, has not been studied. The Delta(6)-desaturase enzyme converts ALA into EPA and DHA, and genetic variation in the Delta(6)-desaturase gene (FADS2) may affect this conversion....
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