Article
Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
PLoS genetics - 1 Jul 2011
Lemaitre Rozenn N, Tanaka Toshiko, Tang Weihong, Manichaikul Ani, Foy Millennia, Kabagambe Edmond K, Nettleton Jennifer A, King Irena B, Weng Lu-Chen, Bhattacharya Sayanti, Bandinelli Stefania, Bis Joshua C, Rich Stephen S, Jacobs David R, Cherubini Antonio, McKnight Barbara, Liang Shuang, Gu Xiangjun, Rice Kenneth, Laurie Cathy C, Lumley Thomas, Browning Brian L, Psaty Bruce M, Chen Yii-Der I, Friedlander Yechiel, Djousse Luc, Wu Jason H Y, Siscovick David S, Uitterlinden André G, Arnett Donna K, Ferrucci Luigi, Fornage Myriam, Tsai Michael Y, Mozaffarian Dariush, Steffen Lyn M
Abstract excerpt
Long-chain n-3 polyunsaturated fatty acids (PUFAs) can derive from diet or from α-linolenic acid (ALA) by elongation and desaturation. We investigated the association of common genetic variation with plasma phospholipid levels of the four major n-3 PUFAs by performing genome-wide association studies in five population-based cohorts comprising 8,866 subjects of European ancestry. Minor alleles of SNPs in FADS1 and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.