Article
Polymorphisms of the apolipoprotein E gene regulatory region and of the LDL receptor gene in late-onset Alzheimer's disease in relation to the plasma lipidic pattern.
Dementia and geriatric cognitive disorders - 1 Jan 2000
Scacchi R, Gambina G, Martini M C, Ruggeri M, Ferrari G, Silvestri M, Schiavon R, Corbo R M
Abstract excerpt
Two new polymorphisms in the regulatory region of the apolipoprotein E gene, -491 A/T and -427 T/C, have been reported to be associated with the risk of Alzheimer's disease (AD). Moreover, in vitro studies suggest that the two polymorphisms modulate the levels of apoE protein expression. We examined these two polymorphisms, as well as the MspI polymorphism in the LDL receptor gene, in a series of elderly patients...
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