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Article

Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation.

Journal of neurochemistry - 1 Mar 2009

Crouch Peter J, Tew Deborah J, Du Tai, Nguyen Diem Ngoc, Caragounis Aphrodite, Filiz Gulay, Blake Rachel E, Trounce Ian A, Soon Cynthia P W, Laughton Katrina, Perez Keyla A, Li Qiao-Xin, Cherny Robert A, Masters Colin L, Barnham Kevin J, White Anthony R

Abstract excerpt

Accumulation of neurotoxic amyloid-beta (Abeta) is central to the pathology of Alzheimer's disease (AD). Elucidating the mechanisms of Abeta accumulation will therefore expedite the development of Abeta-targeting AD therapeutics. We examined activity of an Abeta-degrading protease (matrix metalloprotease 2) to investigate whether biochemical factors consistent with conditions in the AD brain contribute to Abeta...

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Identifiers

PMID: 19141082
DOI: 10.1111/j.1471-4159.2009.05870.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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