Article

Reexamining the Role of Amyloid β Clearance from the Brain: Exporting Labile Iron from the Interstitial Fluid Performs a Protective Function

2025-12-25

Abstract excerpt

Advantageous functions have been attributed to amyloid β, which helps explain its expression despite a propensity to aggregate. Besides supporting cognitive processes, it has antimicrobial activity, e.g., amyloid β can entrap pathogens or disrupt their membranes. Since iron is an essential element for invading organisms, limiting its availability is an antimicrobial strategy. This can be achieved by various means,...

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Literature Corpus work: ef27f88f-87d7-5c8c-aeec-44ae45fa43d5
DOI: 10.20944/preprints202512.2315.v1

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