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Article

Empirical Bayes correction for the Winner's Curse in genetic association studies.

Genetic epidemiology - 1 Jan 2013

Ferguson John P, Cho Judy H, Yang Can, Zhao Hongyu

Abstract excerpt

We consider an Empirical Bayes method to correct for the Winner's Curse phenomenon in genome-wide association studies. Our method utilizes the collective distribution of all odds ratios (ORs) to determine the appropriate correction for a particular single-nucleotide polymorphism (SNP). We can show that this approach is squared error optimal provided that this collective distribution is accurately estimated in its...

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Identifiers

PMID: 23012258
DOI: 10.1002/gepi.21683
PMCID: PMC4048064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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