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Article

TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity

12 Jan 2009

Abstract excerpt

The role of various p73 isoforms in tumorigenesis has been controversial. However, as we have recently shown, the generation of TAp73-deficient (TAp73(-/-)) mice reveals that TAp73 isoforms exert tumor-suppressive functions, indicating an emerging role for Trp-73 in the maintenance of genomic stability. Unlike mice lacking all p73 isoforms, TAp73(-/-) mice show a high incidence of spontaneous tumors. Moreover,...

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PMID: 19139399
DOI: 10.1073/pnas.0812096106

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