Article
Molecular characterization of the role of the Schizosaccharomyces pombe nip1+/ctp1+ gene in DNA double-strand break repair in association with the Mre11-Rad50-Nbs1 complex.
Molecular and cellular biology - 1 Jun 2008
Akamatsu Yufuko, Murayama Yasuto, Yamada Takatomi, Nakazaki Tomofumi, Tsutsui Yasuhiro, Ohta Kunihiro, Iwasaki Hiroshi
Abstract excerpt
The Schizosaccharomyces pombe nip1(+)/ctp1(+) gene was previously identified as an slr (synthetically lethal with rad2) mutant. Epistasis analysis indicated that Nip1/Ctp1 functions in Rhp51-dependent recombinational repair, together with the Rad32 (spMre11)-Rad50-Nbs1 complex, which plays important roles in the early steps of DNA double-strand break repair. Nip1/Ctp1 was phosphorylated in asynchronous,...
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