Article
Functional Crosstalk between the PP2A and SUMO Pathways Revealed by Analysis of STUbL Suppressor, razor 1-1.
PLoS genetics - 1 Jul 2016
Nie Minghua, Arner Emily, Prudden John, Schaffer Lana, Head Steven, Boddy Michael N
Abstract excerpt
Posttranslational modifications (PTMs) provide dynamic regulation of the cellular proteome, which is critical for both normal cell growth and for orchestrating rapid responses to environmental stresses, e.g. genotoxins. Key PTMs include ubiquitin, the Small Ubiquitin-like MOdifier SUMO, and phosphorylation. Recently, SUMO-targeted ubiquitin ligases (STUbLs) were found to integrate signaling through the SUMO and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
