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Article

Slx5 promotes transcriptional silencing and is required for robust growth in the absence of Sir2.

Molecular and cellular biology - 1 Feb 2008

Darst Russell P, Garcia Sandra N, Koch Melissa R, Pillus Lorraine

Abstract excerpt

The broadly conserved Sir2 NAD(+)-dependent deacetylase is required for chromatin silencing. Here we report the discovery of physical and functional links between Sir2 and Slx5 (Hex3), a RING domain protein and subunit of the Slx5/8 complex, [corrected] which is a ubiquitin E3 ligase that targets sumoylated proteins. Slx5 interacted with Sir2 by two-hybrid and glutathione S-transferase-binding assays and was...

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Identifiers

PMID: 18086879
DOI: 10.1128/MCB.01291-07
PMCID: PMC2258744

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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