G-T haplotype (2677G>T/A and 3435C>T) of ABCB1 gene polymorphisms is associated with ethnic differences to paclitaxel sensitivity in cancer cells with different gene expression pattern.

Abstract excerpt

At 2677, the GG and TT were most frequent in Asian cell lines, whereas the GT and GG were most frequent in non-Asians (p=0.032). At 3435, TT and CC was most common in Asians and non-Asians, respectively (p=0.018). A higher IC(50) was found in GG than GT/A genotype (p=0.02) and in G-C than G-T haplotype (p=0.046). Non-Asian cell lines were more sensitive to paclitaxel than Asian cell lines (p=0.01) due to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antineoplastic Agents, Phytogenic
• Share to Asian People