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Article

Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer.

Scientific reports - 9 May 2014

Gao Bo, Russell Amanda, Beesley Jonathan, Chen Xiao Qing, Healey Sue, Henderson Michelle, Wong Mark, Emmanuel Catherine, Galletta Laura, Johnatty Sharon E, Bowtell David, Haber Michelle, Norris Murray, Harnett Paul, Chenevix-Trench Georgia, Balleine Rosemary L, deFazio Anna

Abstract excerpt

ABCB1 (adenosine triphosphate-binding cassette transporter B1) mediates cellular elimination of many chemotherapeutic agents including paclitaxel, which is commonly used to treat ovarian cancer. A significant association between common single nucleotide polymorphisms (SNPs) in ABCB1 and progression-free survival has been reported in patients with ovarian cancer. Variable paclitaxel clearance due to genotype...

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Share to Antineoplastic Agents
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to ABCB1 gene

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Share to Ovarian Neoplasms

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Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 24810093
DOI: 10.1038/srep04669
PMCID: PMC4015028

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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