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Article

Association of the ABCB1 gene polymorphisms 2677G>T/A and 3435C>T with clinical outcomes of paclitaxel monotherapy in metastatic breast cancer patients.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Feb 2009

Chang H, Rha S Y, Jeung H-C, Im C-K, Ahn J B, Kwon W S, Yoo N C, Roh J K, Chung H C

Abstract excerpt

BACKGROUND: ABCB1 is responsible for multidrug resistance, the principal mechanism by which many cancers develop resistance to chemotherapeutic drugs. There is a controversy whether ABCB1 gene polymorphisms correlate with survival and response in cancer patients treated with chemotherapy. We evaluated the association between clinical outcome (safety and efficacy) of paclitaxel monotherapy in metastatic breast...

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Source

Identifiers

PMID: 18836089
DOI: 10.1093/annonc/mdn624

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Association of the ABCB1 gene polymorphisms 2677G>T/A and 3435C>T with clinical outcomes of paclitaxel monotherapy in metastatic breast cancer patients.PMID 18836089Read ↗

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Influence of (C1236T and C3435T) Polymorphisms of ABCB1 Gene on Chemotherapy Treatment Outcome and Toxicity in Breast Cancer Patients.Semantic proximity Read ↗

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Influence of ABCB1 genetic variants in breast cancer treatment outcomes.Semantic proximity Read ↗

The effect of ABCB1 polymorphisms on the outcome of breast cancer treatmentSemantic proximity Read ↗

G-T haplotype (2677G>T/A and 3435C>T) of ABCB1 gene polymorphisms is associated with ethnic differences to paclitaxel sensitivity in cancer cells with different gene expression pattern.Semantic proximity Read ↗

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ABCB1 polymorphism as prognostic factor in breast cancer patients treated with docetaxel and doxorubicin neoadjuvant chemotherapy.Semantic proximity Read ↗

MDR1 (C3435T) polymorphism: relation to the risk of breast cancer and therapeutic outcome.Semantic proximity Read ↗

ABCB1 gene polymorphisms and response to chemotherapy in breast cancer patients: A meta-analysis.Semantic proximity Read ↗

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