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Article

Association of the ABCB1 gene polymorphisms 2677G>T/A and 3435C>T with clinical outcomes of paclitaxel monotherapy in metastatic breast cancer patients.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Feb 2009

Chang H, Rha S Y, Jeung H-C, Im C-K, Ahn J B, Kwon W S, Yoo N C, Roh J K, Chung H C

Abstract excerpt

BACKGROUND: ABCB1 is responsible for multidrug resistance, the principal mechanism by which many cancers develop resistance to chemotherapeutic drugs. There is a controversy whether ABCB1 gene polymorphisms correlate with survival and response in cancer patients treated with chemotherapy. We eval...

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Source

Identifiers

PMID: 18836089
DOI: 10.1093/annonc/mdn624

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18836089-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Association of the ABCB1 gene polymorphisms 2677G>T/A and 3435C>T with clinical outcomes of paclitaxel monotherapy in metastatic breast cancer patients.PMID 18836089Read ↗

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The effect of ABCB1 polymorphisms on the outcome of breast cancer treatmentSemantic proximity Read ↗

G-T haplotype (2677G>T/A and 3435C>T) of ABCB1 gene polymorphisms is associated with ethnic differences to paclitaxel sensitivity in cancer cells with different gene expression pattern.Semantic proximity Read ↗

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ABCB1 polymorphism as prognostic factor in breast cancer patients treated with docetaxel and doxorubicin neoadjuvant chemotherapy.Semantic proximity Read ↗

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