Article
Tropomyosin has discrete actin-binding sites with sevenfold and fourteenfold periodicities.
Journal of molecular biology - 20 Aug 1990
Hitchcock-DeGregori S E, Varnell T A
Abstract excerpt
Analysis of the periodic distribution of amino acids in tropomyosin has revealed the presence of seven or 14 quasi-equivalent actin-binding sites. We tested the hypothesis of periodic actin-binding sites by making deletions of chicken striated alpha-tropomyosin cDNA using oligonucleotide-directed...
Topics
- Actins
- Animals
- Base Sequence
- Binding Sites
- Chickens
- Chromosome Deletion
- DNA
- Escherichia coli
- Iodoacetamide
- Kinetics
- Models, Structural
- Molecular Sequence Data
- Mutation