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Article

Canonical WNT signalling determines lineage specificity in Wilms tumour.

Oncogene - 26 Feb 2009

Fukuzawa R, Anaka M R, Weeks R J, Morison I M, Reeve A E

Abstract excerpt

Wilms tumours (WTs) have two distinct types of histology with or without ectopic mesenchymal elements, suggesting that WTs arise from either the mesenchymal or epithelial nephrogenic lineages. Regardless of the presence or absence of CTNNB1 mutations, nuclear accumulation of beta-catenin is often observed in WTs with ectopic mesenchymal elements. Here, we addressed the relationship between the WNT-signalling...

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Source

Identifiers

PMID: 19137020
DOI: 10.1038/onc.2008.455

Genes

CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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