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Article

Wilms tumour histology is determined by distinct types of precursor lesions and not epigenetic changes.

The Journal of pathology - 1 Aug 2008

Fukuzawa R, Anaka M R, Heathcott R W, McNoe L A, Morison I M, Perlman E J, Reeve A E

Abstract excerpt

Current models of Wilms tumour development propose that histological features of the tumours are programmed by the underlying molecular aberrations. For example, tumours associated with WT1 mutations arise from intralobar nephrogenic rests (ILNR), concur with CTNNB1 mutations and have distinct histology, whereas tumours with IGF2 loss of imprinting (LOI) often arise from perilobar nephrogenic rests (PLNR)....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18484682
DOI: 10.1002/path.2366

Genes

IGF2
CTNNB1
DKK1
MMP2
RARG
SFRP4
WIF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Wilms tumour histology is determined by distinct types of precursor lesions and not epigenetic changes.PMID 18484682Read ↗

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