Insensitivity to the cytolytic effects of glucocorticoids in vivo is associated with a novel "slow death" phenotype.

Article

Insensitivity to the cytolytic effects of glucocorticoids in vivo is associated with a novel "slow death" phenotype.

Cancer research - 15 Oct 1991

Thompson E A

Abstract excerpt

Tumors formed from wild type P1798 mouse lymphoma cells undergo regression when treated with pharmacological doses of natural and synthetic glucocorticoids in vivo. Variants have been selected that are insensitive to the cytolytic effects of glucocorticoids in vivo. Although the response of wild...

Topics

Animals
Cell Death
Cell Division
DNA
Dexamethasone
Drug Resistance
Glucocorticoids
Hydrocortisone
Lymphoma, Non-Hodgkin
Mice
Phenotype
Tumor Cells, Cultured

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