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Article

Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice.

Diabetes - 1 Apr 2009

Hwang Jung Hwan, Kim Dong Wook, Jo Eun Jin, Kim Yong Kyung, Jo Young Suk, Park Ji Hoon, Yoo Sang Ku, Park Myung Kyu, Kwak Tae Hwan, Kho Young Lim, Han Jin, Choi Hueng-Sik, Lee Sang-Hee, Kim Jin Man, Lee InKyu, Kyung Taeyoon, Jang Cholsoon, Chung Jongkyeong, Kweon Gi Ryang, Shong Minho

Abstract excerpt

OBJECTIVE: Nicotinamide adenine dinucleotides (NAD+ and NADH) play a crucial role in cellular energy metabolism, and a dysregulated NAD+-to-NADH ratio is implicated in metabolic syndrome. However, it is still unknown whether a modulating intracellular NAD+-to-NADH ratio is beneficial in treating metabolic syndrome. We tried to determine whether pharmacological stimulation of NADH oxidation provides therapeutic...

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Share to NAD(P)H Dehydrogenase (Quinone)

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Source

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Identifiers

PMID: 19136651
DOI: 10.2337/db08-1183
PMCID: PMC2661596

Genes

NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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