Article
The expression of NAD(P)H:quinone oxidoreductase 1 is high in human adipose tissue, reduced by weight loss, and correlates with adiposity, insulin sensitivity, and markers of liver dysfunction.
The Journal of clinical endocrinology and metabolism - 1 Jun 2007
Palming Jenny, Sjöholm Kajsa, Jernås Margareta, Lystig Theodore C, Gummesson Anders, Romeo Stefano, Lönn Lars, Lönn Malin, Carlsson Björn, Carlsson Lena M S
Abstract excerpt
CONTEXT: We have previously identified nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase 1 (NQO1), an enzyme involved in the protection against oxidative stress, as a gene predominantly expressed in human adipocytes. Studies in mice deficient in NQO1 activity suggest that NQO1 may also play an important role in metabolism. OBJECTIVE: The aim of this study was to explore the expression and...
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