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Article

Regulation of plasminogen activator inhibitor type 1 gene expression by inflammatory mediators and statins

1 Jan 2008

Abstract excerpt

Elevated plasma concentrations of plasminogen activator inhibitor type 1 (PAI-1), also named serpin E1, are encountered in patients with thrombophilia, atherosclerosis, septicemia and the metabolic syndrome and may be associated with an increased risk of complications. Expression of PAI-1 is increased by inflammatory stimuli and decreased by statins, drugs widely used in patients with cardiovascular disease....

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PMID: 19132219
DOI: 10.1160/th08-04-0269

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