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Article

Thrombin promotes proinflammatory phenotype in human vascular smooth muscle cell.

Biochemical and biophysical research communications - 4 Jun 2010

Chung Sung-Woon, Park Jae-Woo, Lee Sae-A, Eo Seong-Kug, Kim Koanhoi

Abstract excerpt

Expression of PAR, the thrombin receptor, is elevated in smooth muscle cell-rich areas in atherosclerotic plaques, where the cells change to proinflammatory or synthetic phenotype. In this study we investigated whether thrombin promotes a proinflammatory phenotype in vascular smooth muscle cell (VSMC), characterized by increased cytokine and chemokine synthesis. Thrombin not only elevated transcripts for IL-6,...

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Source

Identifiers

PMID: 20451499
DOI: 10.1016/j.bbrc.2010.05.009

Genes

CXCL8
CCL11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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