Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Plasminogen Activator Inhibitor Type 1 Gene Polymorphism and Sepsis

19 Oct 2005

Abstract excerpt

Plasminogen activator inhibitor type 1 (PAI-1) is a 50-kilodalton glycoprotein of the serine protease inhibitor family. The primary role of PAI-1 in vivo is the inhibition of both tissue- and urokinase-type plasminogen activators. In addition to this function, PAI-1 acts as an acute-phase protein during acute inflammation. PAI-1 is a pivotal player in the pathogenesis of sepsis, a complex clinical syndrome that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Coagulation and Thrombosis Mechanisms
Share to Blood properties and coagulation
Share to Protease and Inhibitor Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16237647
DOI: 10.1086/431996

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plasminogen Activator Inhibitor Type 1 Gene Polymorphism and SepsisPMID 16237647Read ↗

Role of 4G/5G plasminogen activator inhibitor-1 (PAI-1) gene polymorphism and the PAI-1 plasma levels in the outcome of patients with severe sepsisSemantic proximity Read ↗

PAI-1 genetic polymorphisms influence septic patients' outcomes by regulating neutrophil activity.Semantic proximity Read ↗

Association between plasminogen activator inhibitor-1 -675 4G/5G polymorphism and sepsis: a meta-analysis.Semantic proximity Read ↗

4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic studySemantic proximity Read ↗

4G/5G promoter polymorphism in the plasminogen-activator-inhibitor-1 gene and outcome of meningococcal disease. Meningococcal Research Group.Semantic proximity Read ↗

Association between PAI-1 polymorphisms and plasma PAI-1 level with sepsis in severely burned patients.Semantic proximity Read ↗

Importance of hemostatic gene polymorphisms for susceptibility to and outcome of severe sepsis.Semantic proximity Read ↗

[Relationship of single nucleotide polymorphisms and genetic susceptibility to sepsis].Semantic proximity Read ↗

[Relationship between sepsis and 4G/5G polymorphism within the promoter region of plasminogen activator inhibitor-1 gene].Semantic proximity Read ↗

Genetic insights into sepsis: what have we learned and how will it help?Semantic proximity Read ↗

Genetic polymorphisms in sepsis and septic shock: role in prognosis and potential for therapy.Semantic proximity Read ↗

Variation in plasminogen-activator-inhibitor-1 gene and risk of meningococcal septic shock.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.