Article
Genetic code supports targeted insertion of two amino acids by one codon.
Science (New York, N.Y.) - 9 Jan 2009
Turanov Anton A, Lobanov Alexey V, Fomenko Dmitri E, Morrison Hilary G, Sogin Mitchell L, Klobutcher Lawrence A, Hatfield Dolph L, Gladyshev Vadim N
Abstract excerpt
Strict one-to-one correspondence between codons and amino acids is thought to be an essential feature of the genetic code. However, we report that one codon can code for two different amino acids with the choice of the inserted amino acid determined by a specific 3' untranslated region structure and location of the dual-function codon within the messenger RNA (mRNA). We found that the codon UGA specifies...
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