Anticodon Modifications in the tRNA Set of LUCA and the Fundamental Regularity in the Standard Genetic Code.

doi:10.1371/journal.pone.0158342

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Article

Anticodon Modifications in the tRNA Set of LUCA and the Fundamental Regularity in the Standard Genetic Code.

PloS one - 1 Jan 2016

van der Gulik Peter T S, Hoff Wouter D

Abstract excerpt

Based on (i) an analysis of the regularities in the standard genetic code and (ii) comparative genomics of the anticodon modification machinery in the three branches of life, we derive the tRNA set and its anticodon modifications as it was present in LUCA. Previously we proposed that an early ancestor of LUCA contained a set of 23 tRNAs with unmodified anticodons that was capable of translating all 20 amino acids...

Topics

Anticodon
Archaea
Bacteria
Codon
Eukaryota
Evolution, Molecular
Genetic Code
Genetic Variation
RNA, Transfer

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Identifiers

PMID: 27454314
DOI: 10.1371/journal.pone.0158342
PMCID: PMC4959769

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