Article
Alternative processing of proproteins in Aspergilli kexB gene disruptants under hyperosmotic conditions.
Bioscience, biotechnology, and biochemistry - 1 Jan 2009
Mizutani Osamu, Furukawa Kentaro, Ichiyanagi Shunsuke, Matsuda Yoshihiko, Tokuoka Masafumi, Fujioka Tomonori, Yamagata Youhei, Gomi Katsuya, Abe Keietsu
Abstract excerpt
Disruption of the kexB gene encoding a subtilisin-like processing protease in Aspergillus oryzae and Aspergillus nidulans led to remarkable morphological defects, and these phenotypes were suppressed under hyperosmotic conditions. In this study, we investigated to determine whether non-KexB proteases might complement the in vivo function of KexB in the two Aspergillus kexB disruptants. Neither overexpression of...
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