Article
Kexin-like endoprotease KexB is required for N-glycan processing, morphogenesis and virulence in Aspergillus fumigatus.
Fungal genetics and biology : FG & B - 1 Mar 2015
Wang Jingyang, Zhou Hui, Lu Hua, Du Ting, Luo Yuanming, Wilson Iain B H, Jin Cheng
Abstract excerpt
Kexin-like proteins belong to the subtilisin-like family of the proteinases that cleave secretory proproteins to their active forms. Several fungal kexin-like proteins have been investigated. The mutants lacking of kexin-like protein display strong phenotypes such as cell wall defect, abnormal polarity, and, in case of Candida albicans, diminished virulence. However, only several proteins have been confirmed as...
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