Article
Tumor-specific activation of hTERT-derived promoters by tumor suppressive E1A-mutants involves recruitment of p300/CBP/HAT and suppression of HDAC-1 and defines a combined tumor targeting and suppression system.
Oncogene - 14 Nov 2002
Kirch Hans-Christoph, Ruschen Sabine, Brockmann Dieter, Esche Helmut, Horikawa Izumi, Barrett J Carl, Opalka Bertram, Hengge Ulrich R
Abstract excerpt
Adenovirus (Ad) E1A proteins are transcriptional regulators with antioncogenic but also transforming properties. We have previously shown that transformation-defective Ad5 E1A-derivatives are excellent tumor suppressors. For tumor-specific expression of the E1A-derivatives we intend to use tumor specific human telomerase reverse transcriptase (hTERT) core promoters. Here, we show that Spm2 and other E1A proteins...
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