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Article

Peroxiredoxin 5 confers protection against oxidative stress and apoptosis and also promotes longevity in Drosophila.

The Biochemical journal - 15 Apr 2009

Radyuk Svetlana N, Michalak Katarzyna, Klichko Vladimir I, Benes Judith, Rebrin Igor, Sohal Rajindar S, Orr William C

Abstract excerpt

Peroxiredoxin 5 is a distinct isoform of the peroxiredoxin gene family. The antioxidative and anti-apoptotic functions of peroxiredoxin 5 have been extensively demonstrated in cell culture experiments. In the present paper, we provide the first functional analysis of peroxiredoxin 5 in a multicellular organism, Drosophila melanogaster. Similar to its mammalian, yeast or human counterparts, dPrx5 (Drosophila...

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Identifiers

PMID: 19128239
DOI: 10.1042/BJ20082003
PMCID: PMC2842572

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